Copied Cell Cycle Deregulation in Cancer
Cell Cycle Deregulation in Cancer
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
Price Comparison
| Seller | Contact Seller | List Price | On Sale | Shipping | Best Promo | Final Price | Volume Discount | Financing | Availability | Seller's Page |
|---|---|---|---|---|---|---|---|---|---|---|
|
BEST PRICE 1 Product Purchase
|
|
$129.00 | $129.00 |
|
$129.00 | See Site | In stock | Visit Store |
Reviews
Questions & Answers
Denken und Problemlsen
$59.99
Acoustical Imaging
$109.99
Advanced Research on Computer Science and Information Engineering
$109.99
The Chemical Reactor from Laboratory to Industrial Plant
$129.99
Clinical Mentation Evaluation
$49.99
Rhythmische und schwach rhythmische Abbildungen
$54.99
Drug Abuse
$39.99
Puritans and Catholics in the Trans-Atlantic World 1600-1800
$32.99
Managing Media Businesses
$44.99
Managing the Future of Southeast Asia's Valuable Tropical Rainforests
$169.99
Integration der Qualittsbeurteilung in die Fertigungsttigkeit
$69.99
All About Maude - A High-Performance Logical Framework
$79.99
Probabilities, Laws, and Structures
$169.99
Performance Analysis of Network Architectures
$84.99
Benutzerhandbuch fr die interaktive Geometrie-Software
$59.99
Nationenimages und ffentliches Vertrauen zwischen Staaten
$39.99
Conversations Around Semiotic Engineering
$109.99
Vrancea Earthquakes: Tectonics, Hazard and Risk Mitigation
$129.00
Medizinsche Tauchfibel
$54.99
Die Politik der Bundeslnder
$44.99
Blockchain and Supply Chain Logistics
$69.99
Mit den richtigen Fragen den passenden Berufsweg finden
$24.99
Adaptation and Mitigation Strategies for Climate Change
$229.00
Supervision und professionelles Handeln Pflegender
$59.99
Looking to the Future
$49.99
Genomics of Tree Crops
$249.99
Too Good To Fail
$54.99
The Legal Challenges of the Fourth Industrial Revolution
$199.99
Reflection and Action
$109.99
Das Geschlechterverhltnis als Machtprozess
$69.99
Unconventional Photoactive Solids
$39.99
Juristische Schlsselqualifikationen
$24.99
Analyse von Tabellen und kategorialen Daten
$37.99
Fraud and Corruption in EU Funding
$49.99
Galatea by Madeline Miller
$12.00
The Deep-Sky Observers Year
$54.99
Applications of EPR in Radiation Research
$169.99
14th International Probabilistic Workshop
$169.00
Open-Economy Macroeconomics
$74.99
Translational Bioinformatics for Therapeutic Development
$109.00
