Copied Cell Cycle Deregulation in Cancer
Cell Cycle Deregulation in Cancer
Cancer is fundamentally a disease of abnormal cell proliferation: Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal imbalances, disorganized mitotic spindles), and the proliferative history of the cell (normal generational times). Some of the key oncogenic events in cancer directly perturb proteins that regulate progression through the cell division cycle, others alter cell cycle progression indirectly, through effects on signaling pathway that impinge on the cell cycle. This biology is fundamentally important in cancer therapy. Many of the workhorse treatments for cancer rely on killing proliferating cells. Furthermore, there is growing recognition that stem cell-transit amplifying cell hierarchies may persist or be generated during tumorigenesis, generating important functional heterogeneity in cell cycle control among tumor cells, with far-reaching scientific and clinical implications. This volume outlines major cell cycle perturbations that drive tumorigenesis and considers the prospects for using such knowledge in cancer therapy.
Price Comparison
| Seller | Contact Seller | List Price | On Sale | Shipping | Best Promo | Final Price | Volume Discount | Financing | Availability | Seller's Page |
|---|---|---|---|---|---|---|---|---|---|---|
|
BEST PRICE 1 Product Purchase
|
|
$129.00 | $129.00 |
|
$129.00 | See Site | In stock | Visit Store |
Reviews
Questions & Answers
Unvergngliche Geometrie
$44.99
Doping Dokumente
$44.99
Representing Others in Medieval Iberian Literature
$54.99
A New Paradigm for International Business
$129.00
Disruption durch digitale Plattform-kosysteme
$39.99
Sustainable Practices in Higher Education
$139.99
Aerodynamik axialer Turbokompressoren
$109.00
At some point there has to be peace and quiet!
$84.99
Geometric Group Theory
$109.99
Conflict and Compromise
$54.99
Adaptive Scalarization Methods in Multiobjective Optimization
$109.99
Chemistry and Radioastronomy
$54.99
Progress in Turbulence and Wind Energy IV
$169.00
Empathy
$139.99
Infektionskrankheiten in der Pdiatrie 50 Fallstudien
$49.99
Investigation of Nanoscopic Dynamics and Potentials by Interferometric Scattering Microscopy
$119.99
Bucket Filling from A to Z
$5.96
Consumer Segment LOHAS
$17.99
Das Mikroskop und seine Anwendung
$49.99
Bauen mit DIN-Normen
$59.99
Axonal Branching and Recovery of Coordinated Muscle Activity after Transsection of the Facial Nerve
$84.99
The Calabar Bean and its Alkaloids
$149.00
Materials and Processes of Electron Devices
$84.99
Experimental and Clinical Neuropathology
$109.99
Spatial Filtering for the Control of Smart Structures
$84.99
Sustainable Development Goals and Pandemic Planning
$229.00
Favorite Books for Preschoolers 3
$185.00
Programmentwicklung
$69.99
The Judicialization of Politics in Latin America
$54.99
Festigkeitslehre Verstndnisaufgaben
$39.99
Power Switching Components
$109.99
The Network Organization
$64.99
Entropy Coders of the H.264/AVC Standard
$129.00
Tumor Microenvironments in Organs
$149.00
Biogeography and Ecology in Australia
$54.99
Amperometric and Impedance Monitoring Systems for Biomedical Applications
$109.99
ber die Entwicklung zulssiger Funktionen nach den Eigenfunktionen bei definiten, selbstadjungierte
$54.99
High Performance Computing
$79.99
Leveraging Knowledge Assets
$54.99
Arbeitszeitverkrzung
$59.99
