Compare Prices | Create Shopping Lists with Price Drop Alerts | Set Coupons, Promo Codes & Sales Alerts | Get Access to Exclusive Deals and Much More... All in One Place | Read all about it here

The Sliding-Filament Theory of Muscle Contraction

The Sliding-Filament Theory of Muscle Contraction

Brand
Springer Nature
Manufacturer
N/A
Part Number
0
GTIN
9783030035266
Condition
New
Product Description

Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other. Sliding filaments and the working-stroke mechanism provide the framework for individual myosin motors to act in parallel, generating tension and loaded shortening with an efficient use of chemical energy. Our knowledge of this exquisitely structured molecular machine has exploded in the last four decades, thanks to a bewildering array of techniques for studying intact muscle, muscle fibres, myofibrils and single myosin molecules. After reviewing the mechanical and biochemical background, this monograph shows how old and new experimental discoveries can be modelled, interpreted and incorporated into a coherent mathematical theory of contractility at the molecular level. The theory is applied to steady-state and transient phenomena in muscle fibres, wing-beat oscillations in insect flight muscle, motility assays and single-molecule experiments with optical trapping. Such a synthesis addresses major issues, most notably whether a single myosin motor is driven by a working stroke or a ratchet mechanism, how the working stroke is coupled to phosphate release, and whether one cycle of attachment is driven by the hydrolysis of one molecule of ATP. Ways in which the theory can be extended are explored in appendices. A separate theory is required for the cooperative regulation of muscle by calcium via tropomyosin and troponin on actin filaments. The book reviews the evolution of models for actin-based regulation, culminating in a model motivated by cryo-EM studies where tropomyosin protomers are linked to form a continuous flexible chain. It also explores muscle behaviour as a function of calcium level, including emergent phenomena such as spontaneous oscillatory contractions and direct myosin regulation by its regulatory light chains. Contraction models can be extended to all levels of calcium-activation by embedding them in a cooperative theory of thin-filament regulation, and a method for achieving this grand synthesis is proposed. Dr. David Aitchison Smith is a theoretical physicist with thirty years of research experience in modelling muscle contractility, in collaboration with experimental groups in different laboratories.

Available Colors
Available Sizes
1 Offer Price Range: $129.00 - $129.00
BEST PRICE

Single Product Purchase

$116.10
@ Link.springer.com with extra coupon Get Coupon & BUY

Price Comparison

Seller Contact Seller List Price On Sale Shipping Best Promo Final Price Volume Discount Financing Availability Seller's Page
BEST PRICE
1 Product Purchase
@ Link.springer.com
Contact Store Call Store Contact Support
$129.00 $129.00

10% OFF
This deals requires coupon Get Code Here
$116.10
See Site In stock Visit Store

Similar Products

Metastasis / Dissemination

$109.99

Open Varieties of Capitalism

$54.99

Object-Oriented Technology. ECOOP'99 Workshop Reader

$39.99

Introduction to Satellite Ground Segment Systems Engineering

$159.99

JavaServer Faces

$34.99

Robustness of Dynamic Systems with Parameter Uncertainties

$39.99

Slope Stochastic Dynamics

$159.99

Mehrkrpersysteme

$39.99

Tardive Dyskinesia

$109.99

Cryogenic Operation of Silicon Power Devices

$84.99

Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology

$84.99

The Trajectory of Global Education Policy

$109.99

Patterns of Economic Behaviour Among the American Poor

$59.99

Elektronische Bankvertriebswege

$59.99

Cardiomyopathies and Heart Failure

$299.99

Polyadenylation

$169.99

Betriebswirtschaftliche Systemtheorie

$39.99

Sustainability in Energy and Buildings

$219.99

The Transmission of Kapsiki-Higi Folktales over Two Generations

$39.99

Squished: A Graphic Novel (Hardcover)

$18.74

Expert SQL Server 2008 Encryption

$49.99

Reciprocal Learning between Canada and China in Language and Culture Education

$159.99

Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges

$49.99

New Technologies, Development and Application VI

$329.99

Koordination von Innovationsprojekten

$69.99

Information Loss in Deterministic Signal Processing Systems

$84.99

Peroxiredoxin Systems

$219.99

Einfhrung in die Algebra

$49.99

Biomedical Ethics Reviews 1989

$39.99

Enhancing Police Integrity

$99.00

Mediendesign fr Studium und Beruf

$119.99

Integraler baulicher Erdbebenschutz I: Schutzauftrag Begriffe rechnerischer Nachweis

$54.99

Vladimir Solovyev and Max Scheler: Attempt at a Comparative Interpretation

$54.99

Advances in Stromatolite Geobiology

$169.99

Mndliche Prfung Bankkaufmann/-frau

$39.99

Handbook of Multimodal and Spoken Dialogue Systems

$219.99

Kommunikation im Krisenmodus

$49.99

Individual- und Kompositionseffekte und der Kompetenzzuwachs in Mathematik und Naturwissenschaft am

$44.99

Probability and Information

$449.99

Die geburtshilfliche Ansthesie

$109.00